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Indeed, many have exploited self-assembling peptide domains found widely in nature as cross-linking points between polymers or proteins for hydrogel formation ( 4– 11). Although a variety of materials have been developed that demonstrate these beneficial properties ( 2, 3), there is a dearth of systems sufficiently simple and cost-effective to manufacture on large scales to enable their utility in a range of industrial settings. These hydrogels can exhibit viscous flow under shear stress (shear thinning) and rapid recovery when the applied stress is relaxed (self-healing). Moldable networks (or hydrogels in the case of an aqueous solvent) exploit specific and tunable noncovalent interactions and exhibit many of the properties of traditional chemically cross-linked hydrogels however, they allow for precise tuning of flow properties of physically cross-linked hydrogels to meet the engineering requirements for diverse applications, from injection, pumping, or spraying. Recent advances in supramolecular chemistry and materials science are enabling unique solutions to many critical industrial challenges via the production of moldable polymer networks ( 2, 3). However, the irreversibility of their cross-links is severely limiting and many applications would benefit enormously from new technologies allowing for stimuli-responsive aqueous viscosity modification and/or the ability to rearrange their shape in response to applied stress ( 2). Several aqueous-based applications have exploited covalently cross-linked hydrogels, which comprise a class of soft materials that bind and retain large amounts of water and exhibit broadly tunable mechanical properties. The advent of macromolecular chemistry has provided myriad polymeric materials that are used in diverse applications, including as food/cosmetic additives and viscosity modifiers. Moreover, many products and coatings are applied through spraying, which often requires uniform application and tunable retention of solvent and/or product. Applications as diverse as hydraulic fracturing and cosmetics rely on processable fluids with complex viscoelastic properties. Inefficiencies arise in manufacturing because large volumes of material need to be pumped from one location to another and vast lengths of pipe of varying diameters must be cleaned frequently ( 1). Industrial settings present many unique and complicated engineering challenges. In particular, we demonstrate their utility as injectable materials for pipeline maintenance and product recovery in industrial food manufacturing as well as their use as sprayable carriers for robust application of fire retardants in preventing wildland fires. The facile and scalable preparation of these materials leveraging self-assembly of inexpensive, renewable, and environmentally benign starting materials, coupled with the tunability of their properties, make them amenable to a range of industrial applications. We show that the self-assembly process for gel formation is easily scaled in a linear fashion from 0.5 mL to over 15 L without alteration of the mechanical properties of the resultant materials. Cellulose derivatives are linked together by selective adsorption to silica nanoparticles via dynamic and multivalent interactions. Here, we demonstrate a paradigm for the scalable fabrication of self-assembled moldable hydrogels using rationally engineered, biomimetic polymer–nanoparticle interactions. Industrial implementation of these viscoelastic materials requires extreme volumes of material, upwards of several hundred million gallons per year. Advances in soft material design are yielding next-generation moldable hydrogels that address engineering criteria in several industrial settings such as complex viscosity modifiers, hydraulic or injection fluids, and sprayable carriers. Hydrogels are a class of soft material that is exploited in many, often completely disparate, industrial applications, on account of their unique and tunable properties.